p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function

The p16/RB1 tumor suppressor pathway is inactivated in the vast majority, if not all, human cancers. The current paradigm is that p16 and RB1 function in a linear pathway to suppress tumorigenesis; however p16 is preferentially lost in human cancers suggesting that p16 has critical tumor suppressive...

Descripción completa

Detalles Bibliográficos
Autores principales: Sen, M, Akeno, N, Reece, A, Miller, A L, Simpson, D S, Wikenheiser-Brokamp, K A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520502/
https://www.ncbi.nlm.nih.gov/pubmed/28414317
http://dx.doi.org/10.1038/oncsis.2017.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520502/
https://www.ncbi.nlm.nih.gov/pubmed/28414317
http://dx.doi.org/10.1038/oncsis.2017.5

Ejemplares similares