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p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function
The p16/RB1 tumor suppressor pathway is inactivated in the vast majority, if not all, human cancers. The current paradigm is that p16 and RB1 function in a linear pathway to suppress tumorigenesis; however p16 is preferentially lost in human cancers suggesting that p16 has critical tumor suppressive...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520502/ https://www.ncbi.nlm.nih.gov/pubmed/28414317 http://dx.doi.org/10.1038/oncsis.2017.5 |