Cargando…

Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer

Stage II colon cancer (CC) still remains a clinical challenge with patient stratification for adjuvant therapy (AT) largely relying on clinical parameters. Prognostic biomarkers are urgently needed for better stratification. Previously, we have shown that WNT target genes AXIN2, DKK1, APCDD1, ASCL2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kandimalla, R, Linnekamp, J F, van Hooff, S, Castells, A, Llor, X, Andreu, M, Jover, R, Goel, A, Medema, J P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520503/ https://www.ncbi.nlm.nih.gov/pubmed/28368388 http://dx.doi.org/10.1038/oncsis.2017.9

Ejemplares similares

Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression
por: Linnekamp, Janneke F., et al.
Publicado: (2021)

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins
por: Patel, Saleha, et al.
Publicado: (2018)

Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling
por: Wang, Zhenghan, et al.
Publicado: (2016)

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
por: Tacchelly-Benites, Ofelia, et al.
Publicado: (2018)

The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway
por: Moshkovsky, Ana R., et al.
Publicado: (2022)

New insights into the regulation of Axin function in canonical Wnt signaling pathway
por: Song, Xiaomin, et al.
Publicado: (2014)

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling
por: Callow, Marinella G., et al.
Publicado: (2011)

Roles of Wnt3a and Dkk1 in experimental periodontitis
por: Liu, Jianqi, et al.
Publicado: (2017)

IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer
por: Perez-Carbonell, Lucia, et al.
Publicado: (2014)

Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma
por: Kocemba, Kinga A., et al.
Publicado: (2012)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
por: Lee, Ethan, et al.
Publicado: (2003)

New Immune Role for Axin1 in Colon Cancer Suppression
por: Neufeld, Kristi L.
Publicado: (2022)

Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect
por: Sanson, Romain, et al.
Publicado: (2022)

Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort
por: Fernández-Rozadilla, Ceres, et al.
Publicado: (2010)

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin
por: Gillis, William Q., et al.
Publicado: (2016)

Engineering potent long-acting variants of the Wnt inhibitor DKK2
por: Sopko, Richelle, et al.
Publicado: (2017)

DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability
por: Muto, Yuta, et al.
Publicado: (2014)

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
por: Peng, Yin, et al.
Publicado: (2021)

Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Publicado: (2004)

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization
por: Fagotto, François, et al.
Publicado: (1999)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
por: Bao, Renyue, et al.
Publicado: (2012)

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
por: Goto, Toshiyasu, et al.
Publicado: (2016)

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
por: Ji, Lei, et al.
Publicado: (2019)

HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer
por: Qi, Lina, et al.
Publicado: (2021)

A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype
por: Fessler, E, et al.
Publicado: (2016)

Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity
por: Ali, Hira, et al.
Publicado: (2019)

Niclosamide and Pyrvinium Are Both Potential Therapeutics for Osteosarcoma, Inhibiting Wnt–Axin2–Snail Cascade
por: Yi, Young, et al.
Publicado: (2021)

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway
por: Wang, Yuting, et al.
Publicado: (2022)

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation
por: Ji, Lei, et al.
Publicado: (2017)

Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines
por: Wang, Wenhui, et al.
Publicado: (2021)

Distinct roles of DKK1 and DKK2 in tumor angiogenesis
por: Park, Hongryeol, et al.
Publicado: (2013)

The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis
por: Guo, Yanchun, et al.
Publicado: (2019)

Expression of DKK1 in Endometrial Endometrioid Carcinoma and Its Correlation with Wnt/β-catenin Signalling Pathway
por: Das, Abhijit, et al.
Publicado: (2023)

The Roles of the Wnt-Antagonists Axin and Lrp4 during Embryogenesis of the Red Flour Beetle Tribolium castaneum
por: Prühs, Romy, et al.
Publicado: (2017)

An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
por: Bernkopf, Dominic B., et al.
Publicado: (2019)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders
por: Wang, Mengmeng, et al.
Publicado: (2023)

The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types
por: Forget, M-A, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_3b7rk8uanit5r76asd8apjopj1