Cargando…

Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation

Malignant gliomas (MGs) are one of the most common primary brain cancers in adults with a high mortality rate and relapse rate. Thus, finding better effective approaches to treat MGs has become very urgent. Here, we studied the effects of cryptotanshinone (CTS) on MGs in vitro and in vivo, and explo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Liang, Zhang, Sulin, Li, Cuixian, Zhou, Chun, Li, Dong, Liu, Peiqing, Huang, Min, Shen, Xiaoyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520699/ https://www.ncbi.nlm.nih.gov/pubmed/28492557 http://dx.doi.org/10.1038/cddis.2017.174

Ejemplares similares

Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation
por: Ji, Yubin, et al.
Publicado: (2019)

Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma
por: Chen, Zhiguo, et al.
Publicado: (2017)

Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity
por: Wang, Jiye, et al.
Publicado: (2017)

Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3
por: Qi, Chen, et al.
Publicado: (2017)

Cryptotanshinone Attenuated Pathological Cardiac Remodeling In Vivo and In Vitro Experiments
por: Li, Wen-jing, et al.
Publicado: (2023)

Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo
por: Shen, Li, et al.
Publicado: (2017)

Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer
por: Koh, Jin Sung, et al.
Publicado: (2018)

Development of cryptotanshinone-loaded pellets for angina chronotherapy: In vitro/in vivo prediction and evaluation()
por: Li, Zhenghua, et al.
Publicado: (2018)

Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells
por: Jung, Ji Hoon, et al.
Publicado: (2013)

Cryptotanshinone inhibition of mammalian target of rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer
por: Pan, Yanhong, et al.
Publicado: (2017)

Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2016)

Corrigendum to “Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells”
por: Jung, Ji Hoon, et al.
Publicado: (2018)

Cryptotanshinone-Loaded Cerasomes Formulation: In Vitro Drug Release, in Vivo Pharmacokinetics, and in Vivo Efficacy for Topical Therapy of Acne
por: Zuo, Ting, et al.
Publicado: (2016)

Cryptotanshinone Inhibits ERα-Dependent and -Independent BCRP Oligomer Formation to Reverse Multidrug Resistance in Breast Cancer
por: Ni, Wenting, et al.
Publicado: (2021)

Sidestepping SHP2 inhibition
por: Popescu, Bogdan, et al.
Publicado: (2023)

Correction to: Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2018)

Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway
por: Liu, Yadong, et al.
Publicado: (2020)

Retraction Note to: Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2021)

Sensitization of Glioma Cells to Tamoxifen-Induced Apoptosis by Pl3-Kinase Inhibitor through the GSK-3β/β-Catenin Signaling Pathway
por: Li, Cuixian, et al.
Publicado: (2011)

Cucurbitacin I inhibits the proliferation of pancreatic cancer through the JAK2/STAT3 signalling pathway in vivo and in vitro
por: Xu, Dongchao, et al.
Publicado: (2022)

Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells
por: Yang, Yufei, et al.
Publicado: (2018)

Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone
por: He, Xiangjun, et al.
Publicado: (2023)

UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma via Regulating STAT3 Signaling Pathway
por: Pan, Zhenjiang, et al.
Publicado: (2021)

Effects and mechanisms of trifluridine alone or in combination with cryptotanshinone in inhibiting malignant biological behavior of gastric cancer
por: Luo, Pan-Quan, et al.
Publicado: (2023)

miR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression
por: Chen, Zheng-Gang, et al.
Publicado: (2019)

Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage
por: Ye, Zesen, et al.
Publicado: (2023)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia
por: Richine, Briana M., et al.
Publicado: (2016)

Hydroxyapatite nanoparticles inhibit the growth of human glioma cells in vitro and in vivo
por: Chu, Sheng-Hua, et al.
Publicado: (2012)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Fraxetin Inhibits the Proliferation and Metastasis of Glioma Cells by Inactivating JAK2/STAT3 Signaling
por: Qu, Liangchen, et al.
Publicado: (2021)

Cryptotanshinone inhibits proliferation and induces apoptosis of breast cancer MCF-7 cells via GPER mediated PI3K/AKT signaling pathway
por: Shi, Danning, et al.
Publicado: (2022)

Micheliolide Derivative DMAMCL Inhibits Glioma Cell Growth In Vitro and In Vivo
por: An, Yinghong, et al.
Publicado: (2015)

Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo
por: Chen, Hua, et al.
Publicado: (2008)

Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway
por: Guo, Huijun, et al.
Publicado: (2022)

Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization
por: Buck, Sara J. S., et al.
Publicado: (2022)

Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia
por: Cheng, Rubin, et al.
Publicado: (2021)

Cryptotanshinone interferes with chondrocyte apoptosis in osteoarthritis by inhibiting the expression of miR-574-5p
por: Yue, Songtao, et al.
Publicado: (2021)

Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions
por: Chen, Zhang-Ming, et al.
Publicado: (2021)

Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo
por: Yu, Zhiyun, et al.
Publicado: (2015)

Cryptotanshinone Inhibits the Growth of HCT116 Colorectal Cancer Cells Through Endoplasmic Reticulum Stress-Mediated Autophagy
por: Fu, Xiaojing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8cf33prto2dtpkn1g3qkileo64