Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer

Autophagy has a key role in metabolism and impacts on tumorigenesis. Our previous study found that halofuginone (HF) exerts anticancer activity in colorectal cancer (CRC) by downregulating Akt/mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. But whether and how HF regulates auto...

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Detalles Bibliográficos
Autores principales: Chen, Guo-Qing, Gong, Rui-Hong, Yang, Da-Jian, Zhang, Ge, Lu, Ai-Ping, Yan, Siu-Cheong, Lin, Shu-Hai, Bian, Zhao-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520722/
https://www.ncbi.nlm.nih.gov/pubmed/28492544
http://dx.doi.org/10.1038/cddis.2017.203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520722/
https://www.ncbi.nlm.nih.gov/pubmed/28492544
http://dx.doi.org/10.1038/cddis.2017.203

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