Cargando…
Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer
Autophagy has a key role in metabolism and impacts on tumorigenesis. Our previous study found that halofuginone (HF) exerts anticancer activity in colorectal cancer (CRC) by downregulating Akt/mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. But whether and how HF regulates auto...
Autores principales: | Chen, Guo-Qing, Gong, Rui-Hong, Yang, Da-Jian, Zhang, Ge, Lu, Ai-Ping, Yan, Siu-Cheong, Lin, Shu-Hai, Bian, Zhao-Xiang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520722/ https://www.ncbi.nlm.nih.gov/pubmed/28492544 http://dx.doi.org/10.1038/cddis.2017.203 |
Ejemplares similares
-
Cell death mechanisms induced by synergistic effects of halofuginone and artemisinin in colorectal cancer cells
por: Gong, Rui-Hong, et al.
Publicado: (2022) -
Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism
por: Chen, Guo-Qing, et al.
Publicado: (2015) -
Halofuginone — The Multifaceted Molecule
por: Pines, Mark, et al.
Publicado: (2015) -
Dually nanocoated planar waveguides towards multi-parameter sensing
por: Dominguez, Ismel, et al.
Publicado: (2021) -
Interleukin-4 affects microglial autophagic flux
por: Tang, Run-Hong, et al.
Publicado: (2019)