Cargando…

DT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small-cell lung cancer cells

Non-small-cell lung cancer (NSCLC) is the most commonly diagnosed malignant disease with the leading cause of cancer-related death. Combination treatment remains the major strategy in the clinical therapy of NSCLC. Vinorelbine (NVB), a semi-synthetic vinca alkaloid, is used for advanced and metastat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hongyang, Sun, Li, Li, Hang, Lv, Xiaodan, Semukunzi, Herve, Li, Ruiming, Yu, Jun, Yuan, Shengtao, Lin, Sensen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520732/ https://www.ncbi.nlm.nih.gov/pubmed/28542137 http://dx.doi.org/10.1038/cddis.2017.218

Ejemplares similares

Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice
por: Xiu, Jianbo, et al.
Publicado: (2022)

Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment
por: Gibson, James M, et al.
Publicado: (2022)

Camellia nitidissima Chi Extract Potentiates the Sensitivity of Gastric Cancer Cells to Paclitaxel via the Induction of Autophagy and Apoptosis
por: He, Xu, et al.
Publicado: (2019)

SUMOylation inhibits FOXM1 activity and delays mitotic transition
por: Myatt, S S, et al.
Publicado: (2014)

BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas
por: Huang, Shang-Pen, et al.
Publicado: (2021)

The mRNA transportome of the BicD/Egl transport machinery
por: Vazquez-Pianzola, Paula, et al.
Publicado: (2016)

Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo
por: Yu, Xiao-Wen, et al.
Publicado: (2016)

Novel Synergistic Combination of Mitotic Arrest and Promotion of Apoptosis for Treatment of Pancreatic Adenocarcinoma
por: Duan, Zhijian, et al.
Publicado: (2019)

Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop
por: Lin, Sensen, et al.
Publicado: (2017)

2-Methoxyestradiol Induces Mitotic Arrest, Apoptosis, and Synergistic Cytotoxicity with Arsenic Trioxide in Human Urothelial Carcinoma Cells
por: Kuo, Kuan-Lin, et al.
Publicado: (2013)

Mitotic arrest affects clustering of tumor cells
por: Bonnet, Julia, et al.
Publicado: (2021)

Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin
por: Huynh, Walter, et al.
Publicado: (2017)

Biallelic BICD2 Variant is a Novel Candidate for Cohen-Like Syndrome
por: Caglayan, Ahmet Okay, et al.
Publicado: (2022)

A Structural Model for the Core Nup358-BicD2 Interface
por: Gibson, James M., et al.
Publicado: (2023)

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers
por: Chang, Ya-Ching, et al.
Publicado: (2020)

Identification and functional characterization of BICD2 as a candidate disease gene in an consanguineous family with dilated cardiomyopathy
por: Luo, Kai, et al.
Publicado: (2022)

BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation
por: Lee, Hyun Jik, et al.
Publicado: (2018)

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures
por: Splinter, Daniël, et al.
Publicado: (2012)

Dominant spinal muscular atrophy is caused by mutations in BICD2, an important golgin protein
por: Martinez-Carrera, Lilian A., et al.
Publicado: (2015)

In-frame de novo mutation in BICD2 in two patients with muscular atrophy and arthrogryposis
por: Koboldt, Daniel C., et al.
Publicado: (2018)

A homozygous loss-of-function variant in BICD2 is associated with lissencephaly and cerebellar hypoplasia
por: Abdel-Salam, Ghada M. H., et al.
Publicado: (2022)

BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M
por: Gallisà-Suñé, Núria, et al.
Publicado: (2023)

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss
por: Hirsch, Yoel, et al.
Publicado: (2023)

FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation
por: Vaz, Sara, et al.
Publicado: (2021)

Mitotic Arrest in Teratoma Susceptible Fetal Male Germ Cells
por: Western, Patrick S., et al.
Publicado: (2011)

Synergistic Antitumor Efficacy Mediated by Liposomal Co-Delivery of Polymeric Micelles of Vinorelbine and Cisplatin in Non-Small Cell Lung Cancer
por: Wang, Shuhang, et al.
Publicado: (2021)

Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis
por: Mili, Donia, et al.
Publicado: (2016)

FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases
por: Zhang, Zhenwang, et al.
Publicado: (2023)

The cell-penetrating FOXM1 N-terminus (M1-138) demonstrates potent inhibitory effects on cancer cells by targeting FOXM1 and FOXM1-interacting factor SMAD3
por: Zhang, Zhenwang, et al.
Publicado: (2019)

BICD1 expression, as a potential biomarker for prognosis and predicting response to therapy in patients with glioblastomas
por: Huang, Shang-Pen, et al.
Publicado: (2017)

Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo
por: Spriggs, Chelsey C., et al.
Publicado: (2020)

PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors
por: Budzinska, Marta I., et al.
Publicado: (2020)

Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders
por: Yi, Julie, et al.
Publicado: (2023)

Microscopic and Biochemical Hallmarks of BICD2-Associated Muscle Pathology toward the Evaluation of Novel Variants
por: Unger, Andreas, et al.
Publicado: (2023)

Role of BicDR in bristle shaft construction, tracheal development, and support of BicD functions
por: Jejina, Aleksandra, et al.
Publicado: (2023)

Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease
por: Hao, Wenyan, et al.
Publicado: (2023)

Vinorelbine Augments Radiotherapy in Hepatocellular Carcinoma
por: Yeoh, Kheng Wei, et al.
Publicado: (2020)

Vinorelbine – a clinical review
por: Gregory, R K, et al.
Publicado: (2000)

Visualization of Mitotic Arrest of Cell Cycle with Bioluminescence Imaging in Living Animals
por: Zhang, Guo-Jun, et al.
Publicado: (2013)

High-frequency ultrasound analysis of post-mitotic arrest cell death
por: Pasternak, Maurice M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_oa7djba4ll8mrabq4l3908cl41