HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival

Statins are a well-established family of drugs that lower cholesterol levels via the competitive inhibition of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). In addition, the pleiotropic anti-inflammatory effects of statins on T cells make them attractive as therapeutic drugs in...

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Detalles Bibliográficos
Autores principales: Lacher, Sonja M, Bruttger, Julia, Kalt, Bettina, Berthelet, Jean, Rajalingam, Krishnaraj, Wörtge, Simone, Waisman, Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520735/
https://www.ncbi.nlm.nih.gov/pubmed/28542128
http://dx.doi.org/10.1038/cddis.2017.221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520735/
https://www.ncbi.nlm.nih.gov/pubmed/28542128
http://dx.doi.org/10.1038/cddis.2017.221

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