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Aroclor1254 disrupts the blood–testis barrier by promoting endocytosis and degradation of junction proteins via p38 MAPK pathway
The blood–testis barrier (BTB) constituted by coexisting junction apparatus between Sertoli cells (SCs) plays an important role in spermatogenesis, which is a known target of various environmental toxicants. The commercial polychlorinated biphenyls mixture, Aroclor1254, has been shown to impair male...
Autores principales: | Jia, Xiaoyu, Xu, Ying, Wu, Weixing, Fan, Yunxia, Wang, Guoli, Zhang, Tianbiao, Su, Wenhui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520738/ https://www.ncbi.nlm.nih.gov/pubmed/28542131 http://dx.doi.org/10.1038/cddis.2017.224 |
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