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P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Although its pathogenesis remains unclear, mitochondrial dysfunction plays a vital role in the pathology of PD. P7C3, an aminopropyl carbazole, possesses a significant neuroprotective ability in several neurodegenerativ...

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Detalles Bibliográficos
Autores principales: Gu, Chao, Zhang, Yan, Hu, Qingsong, Wu, Jiayuan, Ren, Haigang, Liu, Chun-Feng, Wang, Guanghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520908/
https://www.ncbi.nlm.nih.gov/pubmed/28569794
http://dx.doi.org/10.1038/cddis.2017.250