Cargando…
P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Although its pathogenesis remains unclear, mitochondrial dysfunction plays a vital role in the pathology of PD. P7C3, an aminopropyl carbazole, possesses a significant neuroprotective ability in several neurodegenerativ...
Autores principales: | Gu, Chao, Zhang, Yan, Hu, Qingsong, Wu, Jiayuan, Ren, Haigang, Liu, Chun-Feng, Wang, Guanghui |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520908/ https://www.ncbi.nlm.nih.gov/pubmed/28569794 http://dx.doi.org/10.1038/cddis.2017.250 |
Ejemplares similares
-
P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo
por: Gu, Chao, et al.
Publicado: (2018) -
DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65
por: Lin, Zixuan, et al.
Publicado: (2021) -
Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
por: Liu, Jie, et al.
Publicado: (2015) -
GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib
por: Li, Junyu, et al.
Publicado: (2020) -
Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins
por: Callizot, Noëlle, et al.
Publicado: (2019)