Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia

Lin28A is a highly conserved RNA-binding protein that concurs to control the balance between stemness and differentiation in several tissue lineages. Here, we report the role of miR-128a/Lin28A axis in blocking cell differentiation in acute myeloid leukemia (AML), a genetically heterogeneous disease...

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Detalles Bibliográficos
Autores principales: De Luca, Luciana, Trino, Stefania, Laurenzana, Ilaria, Tagliaferri, Daniela, Falco, Geppino, Grieco, Vitina, Bianchino, Gabriella, Nozza, Filomena, Campia, Valentina, D'Alessio, Francesca, La Rocca, Francesco, Caivano, Antonella, Villani, Oreste, Cilloni, Daniela, Musto, Pellegrino, Del Vecchio, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520910/
https://www.ncbi.nlm.nih.gov/pubmed/28569789
http://dx.doi.org/10.1038/cddis.2017.253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520910/
https://www.ncbi.nlm.nih.gov/pubmed/28569789
http://dx.doi.org/10.1038/cddis.2017.253

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