Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex

The Tumor suppressor SMAR1 (scaffold matrix attachment region binding protein 1) has a crucial role in maintaining genomic stability, cell cycle progression and apoptosis.Our previous finding showed that it is highly suppressed in higher grade of cancer. However, the underlying mechanism of this sup...

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Detalles Bibliográficos
Autores principales: Paul, Debasish, Ghorai, Suvankar, Dinesh, U S, Shetty, Praveenkumar, Chattopadhyay, Samit, Santra, Manas Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520925/
https://www.ncbi.nlm.nih.gov/pubmed/28617439
http://dx.doi.org/10.1038/cddis.2017.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520925/
https://www.ncbi.nlm.nih.gov/pubmed/28617439
http://dx.doi.org/10.1038/cddis.2017.270

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