Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP. Male SHRSP, SHRSR, two reciprocal SHRSR/SHRSP-STR1/QTL stroke congenic lines received JD for 4...

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Detalles Bibliográficos
Autores principales: Rubattu, Speranza, Stanzione, Rosita, Bianchi, Franca, Cotugno, Maria, Forte, Maurizio, Ragione, Floriana Della, Fioriniello, Salvatore, D'Esposito, Maurizio, Marchitti, Simona, Madonna, Michele, Baima, Simona, Morelli, Giorgio, Sciarretta, Sebastiano, Sironi, Luigi, Gelosa, Paolo, Volpe, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520932/
https://www.ncbi.nlm.nih.gov/pubmed/28640254
http://dx.doi.org/10.1038/cddis.2017.278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520932/
https://www.ncbi.nlm.nih.gov/pubmed/28640254
http://dx.doi.org/10.1038/cddis.2017.278

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