Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers

We recently established c-Abl as a potent suppressor of triple-negative breast cancer (TNBC) progression through its reactivation of a p53:p21 signaling axis coupled to senescence. Moreover, we observed co-expression of p53 and c-Abl to be essential for normal mammary epithelial cell physiology, as...

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Detalles Bibliográficos
Autores principales: Morrison, Chevaun D, Chang, Jenny C, Keri, Ruth A, Schiemann, William P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520943/
https://www.ncbi.nlm.nih.gov/pubmed/28661474
http://dx.doi.org/10.1038/cddis.2017.294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520943/
https://www.ncbi.nlm.nih.gov/pubmed/28661474
http://dx.doi.org/10.1038/cddis.2017.294

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