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Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery

BACKGROUND: Fentanyl is often used instead of morphine for the treatment of pain because it has fewer side effects. The metabolism of morphine by glucuronidation is known to be influenced by polymorphisms of the UGT2B7 gene. Some metabolic products of fentanyl are reportedly metabolized by glucurona...

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Autores principales: Muraoka, Wataru, Nishizawa, Daisuke, Fukuda, Kenichi, Kasai, Shinya, Hasegawa, Junko, Wajima, Koichi, Nakagawa, Taneaki, Ikeda, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521342/
https://www.ncbi.nlm.nih.gov/pubmed/28256933
http://dx.doi.org/10.1177/1744806916683182
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author Muraoka, Wataru
Nishizawa, Daisuke
Fukuda, Kenichi
Kasai, Shinya
Hasegawa, Junko
Wajima, Koichi
Nakagawa, Taneaki
Ikeda, Kazutaka
author_facet Muraoka, Wataru
Nishizawa, Daisuke
Fukuda, Kenichi
Kasai, Shinya
Hasegawa, Junko
Wajima, Koichi
Nakagawa, Taneaki
Ikeda, Kazutaka
author_sort Muraoka, Wataru
collection PubMed
description BACKGROUND: Fentanyl is often used instead of morphine for the treatment of pain because it has fewer side effects. The metabolism of morphine by glucuronidation is known to be influenced by polymorphisms of the UGT2B7 gene. Some metabolic products of fentanyl are reportedly metabolized by glucuronate conjugation. The genes that are involved in the metabolic pathway of fentanyl may also influence fentanyl sensitivity. We analyzed associations between fentanyl sensitivity and polymorphisms of the UGT2B7 gene to clarify the hereditary determinants of individual differences in fentanyl sensitivity. RESULTS: This study examined whether single-nucleotide polymorphisms (SNPs) of the UGT2B7 gene affect cold pain sensitivity and the analgesic effects of fentanyl, evaluated by a standardized pain test and fentanyl requirements in healthy Japanese subjects who underwent uniform surgical procedures. The rs7439366 SNP of UGT2B7 is reportedly associated with the metabolism and analgesic effects of morphine. We found that this SNP is also associated with the analgesic effects of fentanyl in the cold pressor-induced pain test. It suggested that the C allele of the rs7439366 SNP may enhance analgesic efficacy. Two SNPs of UGT2B7, rs4587017 and rs1002849, were also found to be novel SNPs that may influence the analgesic effects of fentanyl in the cold pressor-induced pain test. CONCLUSIONS: Fentanyl sensitivity for cold pressor-induced pain was associated with the rs7439366, rs4587017, and rs1002849 SNPs of the UGT2B7 gene. Our findings may provide valuable information for achieving satisfactory pain control and open to new avenues for personalized pain treatment.
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spelling pubmed-55213422017-08-04 Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery Muraoka, Wataru Nishizawa, Daisuke Fukuda, Kenichi Kasai, Shinya Hasegawa, Junko Wajima, Koichi Nakagawa, Taneaki Ikeda, Kazutaka Mol Pain Original Article BACKGROUND: Fentanyl is often used instead of morphine for the treatment of pain because it has fewer side effects. The metabolism of morphine by glucuronidation is known to be influenced by polymorphisms of the UGT2B7 gene. Some metabolic products of fentanyl are reportedly metabolized by glucuronate conjugation. The genes that are involved in the metabolic pathway of fentanyl may also influence fentanyl sensitivity. We analyzed associations between fentanyl sensitivity and polymorphisms of the UGT2B7 gene to clarify the hereditary determinants of individual differences in fentanyl sensitivity. RESULTS: This study examined whether single-nucleotide polymorphisms (SNPs) of the UGT2B7 gene affect cold pain sensitivity and the analgesic effects of fentanyl, evaluated by a standardized pain test and fentanyl requirements in healthy Japanese subjects who underwent uniform surgical procedures. The rs7439366 SNP of UGT2B7 is reportedly associated with the metabolism and analgesic effects of morphine. We found that this SNP is also associated with the analgesic effects of fentanyl in the cold pressor-induced pain test. It suggested that the C allele of the rs7439366 SNP may enhance analgesic efficacy. Two SNPs of UGT2B7, rs4587017 and rs1002849, were also found to be novel SNPs that may influence the analgesic effects of fentanyl in the cold pressor-induced pain test. CONCLUSIONS: Fentanyl sensitivity for cold pressor-induced pain was associated with the rs7439366, rs4587017, and rs1002849 SNPs of the UGT2B7 gene. Our findings may provide valuable information for achieving satisfactory pain control and open to new avenues for personalized pain treatment. SAGE Publications 2016-12-01 /pmc/articles/PMC5521342/ /pubmed/28256933 http://dx.doi.org/10.1177/1744806916683182 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Muraoka, Wataru
Nishizawa, Daisuke
Fukuda, Kenichi
Kasai, Shinya
Hasegawa, Junko
Wajima, Koichi
Nakagawa, Taneaki
Ikeda, Kazutaka
Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
title Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
title_full Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
title_fullStr Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
title_full_unstemmed Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
title_short Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
title_sort association between ugt2b7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521342/
https://www.ncbi.nlm.nih.gov/pubmed/28256933
http://dx.doi.org/10.1177/1744806916683182
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