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Understanding Russell’s viper venom factor V activator’s substrate specificity by surface plasmon resonance and in-silico studies
Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546). Russell’s viper venom factor V activator (RVV-V) is a thrombin-like serine proteinase that activates...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521794/ https://www.ncbi.nlm.nih.gov/pubmed/28732041 http://dx.doi.org/10.1371/journal.pone.0181216 |