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Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity

The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. However, its central function remains unclear. Here we found that Lin28a is highly expressed in the hypothalamus compared with peripheral tissues. Its expression is positively correlated with positive...

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Detalles Bibliográficos
Autores principales: Kim, Jung Dae, Toda, Chitoku, Ramírez, Cristina M., Fernández-Hernando, Carlos, Diano, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521863/
https://www.ncbi.nlm.nih.gov/pubmed/28550108
http://dx.doi.org/10.2337/db16-1558