Cargando…
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition
Modulation of the immune system for the treatment of primary and metastatic tumors has been a goal of cancer research for many years. The E3 ubiquitin ligase Cbl-b has been established as an intracellular checkpoint that limits T cell activation, critically contributing to the maintenance of self-to...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522032/ https://www.ncbi.nlm.nih.gov/pubmed/28611299 http://dx.doi.org/10.18632/oncotarget.18360 |