Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation

Glioblastoma multiforme (GBM) is the most common and deadly brain cancer, characterized by its aggressive proliferation to adjacent tissue and high recurrence rate. We studied the efficacy and related mechanisms of the combination of cyclopamine (Cyp, a Sonic-hedgehog pathway (Shh) inhibitor) and te...

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Detalles Bibliográficos
Autores principales: Liu, Yu-Jie, Ma, Ying-Cong, Zhang, Wen-Jie, Yang, Zhen-Zhen, Liang, De-Sheng, Wu, Zhi-Fu, Qi, Xian-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522083/
https://www.ncbi.nlm.nih.gov/pubmed/28477008
http://dx.doi.org/10.18632/oncotarget.17205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522083/
https://www.ncbi.nlm.nih.gov/pubmed/28477008
http://dx.doi.org/10.18632/oncotarget.17205

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