Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer

Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine metabolism for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that glutamine deprivation retarded cell growth and induced prosurvival autophagy. Autophagy inhibiti...

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Detalles Bibliográficos
Autores principales: Li, Jiaqiu, Song, Ping, Zhu, Liyuan, Aziz, Neelum, Zhou, Qiyin, Zhang, Yulong, Xu, Wenxia, Feng, Lifeng, Chen, Dingwei, Wang, Xian, Jin, Hongchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522096/
https://www.ncbi.nlm.nih.gov/pubmed/28424408
http://dx.doi.org/10.18632/oncotarget.16844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522096/
https://www.ncbi.nlm.nih.gov/pubmed/28424408
http://dx.doi.org/10.18632/oncotarget.16844

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