HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression

Cancer cells develop resistance to therapy by adapting to hypoxic microenvironments, and hypoxia-inducible factors (HIFs) play crucial roles in this process. We investigated the roles of HIF-1α and HIF-2α in cancer cell death induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (...

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Detalles Bibliográficos
Autores principales: Harashima, Nanae, Takenaga, Keizo, Akimoto, Miho, Harada, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522113/
https://www.ncbi.nlm.nih.gov/pubmed/28476028
http://dx.doi.org/10.18632/oncotarget.17157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522113/
https://www.ncbi.nlm.nih.gov/pubmed/28476028
http://dx.doi.org/10.18632/oncotarget.17157

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