6-mercaptopurine promotes energetic failure in proliferating T cells

The anticancer drug 6-mercaptopurine (6-MP) inhibits de novo purine synthesis and acts as an antiproliferative agent by interfering with protein, DNA and RNA synthesis and promoting apoptosis. Metabolic reprogramming is crucial for tumor progression to foster cancer cells growth and proliferation, a...

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Detalles Bibliográficos
Autores principales: Fernández-Ramos, Ana A., Marchetti-Laurent, Catherine, Poindessous, Virginie, Antonio, Samantha, Laurent-Puig, Pierre, Bortoli, Sylvie, Loriot, Marie-Anne, Pallet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522126/
https://www.ncbi.nlm.nih.gov/pubmed/28574837
http://dx.doi.org/10.18632/oncotarget.17889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522126/
https://www.ncbi.nlm.nih.gov/pubmed/28574837
http://dx.doi.org/10.18632/oncotarget.17889

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