Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells

Tissue hypoxia contributes to solid tumor pathogenesis by activating a series of adaptive programs. We previously showed that hypoxia promotes the preferential expansion and maintenance of CD133 positive human glioma stem cells (GSC) in a hypoxia inducible factor 1 alpha (HIF-1α)-dependent mechanism...

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Detalles Bibliográficos
Autores principales: Lee, Dae-Hee, Oh, Sang Cheul, Giles, Amber J., Jung, Jinkyu, Gilbert, Mark R., Park, Deric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522201/
https://www.ncbi.nlm.nih.gov/pubmed/28410215
http://dx.doi.org/10.18632/oncotarget.16714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522201/
https://www.ncbi.nlm.nih.gov/pubmed/28410215
http://dx.doi.org/10.18632/oncotarget.16714

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