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Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells

Tissue hypoxia contributes to solid tumor pathogenesis by activating a series of adaptive programs. We previously showed that hypoxia promotes the preferential expansion and maintenance of CD133 positive human glioma stem cells (GSC) in a hypoxia inducible factor 1 alpha (HIF-1α)-dependent mechanism...

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Detalles Bibliográficos
Autores principales:	Lee, Dae-Hee, Oh, Sang Cheul, Giles, Amber J., Jung, Jinkyu, Gilbert, Mark R., Park, Deric M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522201/ https://www.ncbi.nlm.nih.gov/pubmed/28410215 http://dx.doi.org/10.18632/oncotarget.16714

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