P53 suppresses ribonucleotide reductase via inhibiting mTORC1

Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2) via inhibiting mammalia...

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Detalles Bibliográficos
Autores principales: He, Zhengfu, Hu, Xing, Liu, Weijin, Dorrance, Adrienne, Garzon, Ramiro, Houghton, Peter J., Shen, Changxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522210/
https://www.ncbi.nlm.nih.gov/pubmed/28507282
http://dx.doi.org/10.18632/oncotarget.17440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522210/
https://www.ncbi.nlm.nih.gov/pubmed/28507282
http://dx.doi.org/10.18632/oncotarget.17440

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