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P53 suppresses ribonucleotide reductase via inhibiting mTORC1

Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2) via inhibiting mammalia...

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Detalles Bibliográficos
Autores principales:	He, Zhengfu, Hu, Xing, Liu, Weijin, Dorrance, Adrienne, Garzon, Ramiro, Houghton, Peter J., Shen, Changxian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522210/ https://www.ncbi.nlm.nih.gov/pubmed/28507282 http://dx.doi.org/10.18632/oncotarget.17440

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