Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells

Multiple myeloma is a fetal form of plasma cell malignancy characterized by abnormal clonal proliferation of plasma cells. Especially, the canonical Wnt signaling pathway mediated by β-catenin is activated in multiple myeloma cells, stimulating their proliferation. Here, we investigated the relation...

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Detalles Bibliográficos
Autores principales: Lee, Yura, Jung, Jung-Il, Park, Kyeong-Yong, Kim, Soon Ae, Kim, Jiyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522218/
https://www.ncbi.nlm.nih.gov/pubmed/28467797
http://dx.doi.org/10.18632/oncotarget.17056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522218/
https://www.ncbi.nlm.nih.gov/pubmed/28467797
http://dx.doi.org/10.18632/oncotarget.17056

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