Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners

Excessive and prolonged activation of macrophages underlies many inflammatory and autoimmune diseases. To regulate activation and maintain homeostasis, macrophages have multiple intrinsic mechanisms, one of which is modulation through autophagy. Here we demonstrate that autophagy induction by rapamy...

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Detalles Bibliográficos
Autores principales: Ko, Jung Hwa, Yoon, Sun-Ok, Lee, Hyun Ju, Oh, Joo Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522223/
https://www.ncbi.nlm.nih.gov/pubmed/28489580
http://dx.doi.org/10.18632/oncotarget.17256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522223/
https://www.ncbi.nlm.nih.gov/pubmed/28489580
http://dx.doi.org/10.18632/oncotarget.17256

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