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Tumor immunotherapy: drug-induced neoantigens (xenogenization) and immune checkpoint inhibitors

More than 40 years ago, we discovered that novel transplantation antigens can be induced in vivo or in vitro by treating murine leukemia with dacarbazine. Years later, this phenomenon that we called “Chemical Xenogenization” (CX) and more recently, “Drug-Induced Xenogenization” (DIX), was reproduced...

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Detalles Bibliográficos
Autores principales: Franzese, Ornella, Torino, Francesco, Fuggetta, Maria Pia, Aquino, Angelo, Roselli, Mario, Bonmassar, Enzo, Giuliani, Anna, D’Atri, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522228/
https://www.ncbi.nlm.nih.gov/pubmed/28404974
http://dx.doi.org/10.18632/oncotarget.16335