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Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer
The tumor suppressor microRNA-199b (miR-199b) is a negative SET regulator associated with poor outcome in some human cancers. However, its expression levels as well as potential biological and clinical significance in colorectal cancer (CRC) remain completely unexplored. The PP2A inhibitor SET has s...
Autores principales: | Cristóbal, Ion, Caramés, Cristina, Rincón, Raúl, Manso, Rebeca, Madoz-Gúrpide, Juan, Torrejón, Blanca, González-Alonso, Paula, Rojo, Federico, García-Foncillas, Jesús |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522310/ https://www.ncbi.nlm.nih.gov/pubmed/27517624 http://dx.doi.org/10.18632/oncotarget.11174 |
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