Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity

Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine. We previously have demonstrated that the regulator of G-protein s...

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Detalles Bibliográficos
Autores principales: Chen, I-Shan, Furutani, Kazuharu, Kurachi, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522400/
https://www.ncbi.nlm.nih.gov/pubmed/28733581
http://dx.doi.org/10.1038/s41598-017-05128-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522400/
https://www.ncbi.nlm.nih.gov/pubmed/28733581
http://dx.doi.org/10.1038/s41598-017-05128-z

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