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Influence of C-terminal truncation of murine Serum amyloid A on fibril structure

Amyloid A (AA) amyloidosis is a systemic protein misfolding disease affecting humans and other vertebrates. While the protein precursor in humans and mice is the acute-phase reactant serum amyloid A (SAA) 1.1, the deposited fibrils consist mainly of C-terminally truncated SAA fragments, termed AA pr...

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Detalles Bibliográficos
Autores principales: Rennegarbe, Matthies, Lenter, Inga, Schierhorn, Angelika, Sawilla, Romy, Haupt, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522423/
https://www.ncbi.nlm.nih.gov/pubmed/28733641
http://dx.doi.org/10.1038/s41598-017-06419-1