Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism

Proteasomes are responsible for protein turnover in eukaryotic cells, degrading short-lived species but also removing improperly folded or oxidatively damaged ones. Dysfunction of a proteasome results in gradual accumulation of misfolded/damaged proteins, leading to their aggregation. It has been po...

Descripción completa

Detalles Bibliográficos
Autores principales: Witkowska, Julia, Giżyńska, Małgorzata, Grudnik, Przemysław, Golik, Przemysław, Karpowicz, Przemysław, Giełdoń, Artur, Dubin, Grzegorz, Jankowska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522460/
https://www.ncbi.nlm.nih.gov/pubmed/28733623
http://dx.doi.org/10.1038/s41598-017-05997-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522460/
https://www.ncbi.nlm.nih.gov/pubmed/28733623
http://dx.doi.org/10.1038/s41598-017-05997-4

Ejemplares similares