Integrin α6β4 Upregulates Amphiregulin and Epiregulin through Base Excision Repair-Mediated DNA Demethylation and Promotes Genome-wide DNA Hypomethylation

Aberrant DNA methylation patterns are a common theme across all cancer types. Specific DNA demethylation of regulatory sequences can result in upregulation of genes that are critical for tumor development and progression. Integrin α6β4 is highly expressed in pancreatic carcinoma and contributes to c...

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Detalles Bibliográficos
Autores principales: Carpenter, Brittany L., Liu, Jinpeng, Qi, Lei, Wang, Chi, O’Connor, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522472/
https://www.ncbi.nlm.nih.gov/pubmed/28733611
http://dx.doi.org/10.1038/s41598-017-06351-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522472/
https://www.ncbi.nlm.nih.gov/pubmed/28733611
http://dx.doi.org/10.1038/s41598-017-06351-4

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