Cargando…

PI3K p85α Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production

We investigated the role of the PI3K p85α subunit in the development of acute colitis with a focus on intestinal macrophages. Experimental acute colitis was induced using 3% dextran sulfate sodium (DSS) in drinking water for 7 days. The severity of DSS-induced acute colitis was significantly attenua...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hayashi, Shusaku, Hamada, Takayuki, Zinsou, Donald G. A., Oshiro, Momoe, Itoi, Kana, Yamamoto, Takeshi, Kadowaki, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522489/ https://www.ncbi.nlm.nih.gov/pubmed/28733636 http://dx.doi.org/10.1038/s41598-017-06464-w

Ejemplares similares

Morphological elucidation of short-chain fatty acid receptor GPR41-positive enteric sensory neurons in the colon of mice with dextran sulfate sodium-induced colitis
por: Hertati, Ai, et al.
Publicado: (2020)

Interleukin-4 Receptor α Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo Through the Enhancement of Intestinal Mucosal Barrier Function
por: Hertati, Ai, et al.
Publicado: (2020)

Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells
por: Kanauchi, Yuya, et al.
Publicado: (2022)

Improvement of Therapeutic Efficacy of Oral Immunotherapy in Combination with Regulatory T Cell-Inducer Kakkonto in a Murine Food Allergy Model
por: Nagata, Yuka, et al.
Publicado: (2017)

Therapeutic Benefit in Allergic Dermatitis Derived from the Inhibitory Effect of Byakkokaninjinto on the Migration of Plasmacytoid Dendritic Cells
por: Yamamoto, Takeshi, et al.
Publicado: (2020)

Sphingosine Kinase-1-Dependent and -Independent Inhibitory Effects of Zanthoxyli Fructus to Attenuate the Activation of Mucosal Mast Cells and Ameliorate Food Allergies in Mice
por: Wang, Xiaoyu, et al.
Publicado: (2012)

Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice
por: Yashiro, Tomoe, et al.
Publicado: (2021)

Contribution of IL-12/IL-35 Common Subunit p35 to Maintaining the Testicular Immune Privilege
por: Terayama, Hayato, et al.
Publicado: (2014)

The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling
por: Lee, Junsik M, et al.
Publicado: (2021)

Anti-Allergic Role of Cholinergic Neuronal Pathway via α7 Nicotinic ACh Receptors on Mucosal Mast Cells in a Murine Food Allergy Model
por: Yamamoto, Takeshi, et al.
Publicado: (2014)

PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits
por: Wang, Qi, et al.
Publicado: (2020)

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
por: Ito, Yoshihiro, et al.
Publicado: (2017)

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K
por: Conley, Mary Ellen, et al.
Publicado: (2012)

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit
por: Shriver, Marey, et al.
Publicado: (2016)

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit
por: Neal, Christopher L., et al.
Publicado: (2011)

Structure of 85 kDa Subunit of Human Phosphatidylinositol 3‐Kinase Analyzed by Using Monoclonal Antibodies
por: Tanaka, Shinya, et al.
Publicado: (1993)

Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer
por: Zegarra Ruiz, Daniel F., et al.
Publicado: (2022)

Coincidence studies of pi+ absorption on $^{3}$He at T$_{pi}$ = 65 and 85 MeV
por: Aniol, K A, et al.
Publicado: (1984)

Study of the $\pi^{+}\pi^{+}\pi^{-}\pi^{-}$ system centrally produced by incident $\pi^{+}$ and p beams at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1989)

Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral Replication
por: Li, Huimin, et al.
Publicado: (2018)

The p85 Regulatory Subunit of PI3K Mediates cAMP-PKA and Insulin Biological Effects on MCF-7 Cell Growth and Motility
por: Di Zazzo, E., et al.
Publicado: (2014)

C-terminal domain of p42 Ebp1 is essential for down regulation of p85 subunit of PI3K, inhibiting tumor growth
por: Hwang, Inwoo, et al.
Publicado: (2016)

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
por: Tsolakos, N., et al.
Publicado: (2018)

Absorption of pi- on a T = 1 pair in $^{3}$He at T$_{pi}$ = 65 and 85 MeV
por: Altman, A, et al.
Publicado: (1984)

IL-33 ameliorates experimental colitis involving regulation of autophagy of macrophages in mice
por: Wang, Zhongyan, et al.
Publicado: (2019)

NDUFAF7 Methylates Arginine 85 in the NDUFS2 Subunit of Human Complex I
por: Rhein, Virginie F., et al.
Publicado: (2013)

IL-10 modulates DSS-induced colitis through a macrophage – ROS – NO axis
por: Li, Bofeng, et al.
Publicado: (2013)

IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis
por: Tu, Lei, et al.
Publicado: (2017)

Class I(A) PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes
por: Krishnan, Subha, et al.
Publicado: (2012)

Computational Insights into the Interactions between Calmodulin and the c/nSH2 Domains of p85α Regulatory Subunit of PI3Kα: Implication for PI3Kα Activation by Calmodulin
por: Ni, Duan, et al.
Publicado: (2018)

The pi- + $^{3}$He --> n + d reaction at 65 and 85 MeV
por: Aniol, K A, et al.
Publicado: (1984)

Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis
por: Uchiyama, Kazuhiko, et al.
Publicado: (2021)

Study of the centrally produced $\pi\pi$ and $K\bar{K}$ systems at 85 and 300 GeV/c
por: Armstrong, T A, et al.
Publicado: (1991)

EXM 85-21: 31/10 - 85
por: Malandain, E.
Publicado: (1985)

Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages
por: Tsukuba, Takayuki, et al.
Publicado: (2013)

A study of two-pion states centrally produced in the reactions pi+p --> pi+(pi+pi-)p and pp --> p(pi+pi-)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1985)

Risk factors for postoperative stoma outlet obstruction in ulcerative colitis
por: Kitahara, Tomoaki, et al.
Publicado: (2020)

The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn
por: Demircioglu, F. Esra, et al.
Publicado: (2019)

Saireito (TJ-114), a Japanese Traditional Herbal Medicine, Reduces 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Inhibiting Cytokine-Mediated Apoptosis in Intestinal Crypt Cells
por: Kato, Shinichi, et al.
Publicado: (2015)

KampoDB, database of predicted targets and functional annotations of natural medicines
por: Sawada, Ryusuke, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_trt87vpgm0teq002sq52kdle5k