Big conductance calcium‐activated potassium channel openers control spasticity without sedation

BACKGROUND AND PURPOSE: Our initial aim was to generate cannabinoid agents that control spasticity, occurring as a consequence of multiple sclerosis (MS), whilst avoiding the sedative side effects associated with cannabis. VSN16R was synthesized as an anandamide (endocannabinoid) analogue in an anti...

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Detalles Bibliográficos
Autores principales: Baker, David, Pryce, Gareth, Visintin, Cristina, Sisay, Sofia, Bondarenko, Alexander I, Vanessa Ho, W S, Jackson, Samuel J, Williams, Thomas E, Al‐Izki, Sarah, Sevastou, Ioanna, Okuyama, Masahiro, Graier, Wolfgang F, Stevenson, Lesley A, Tanner, Carolyn, Ross, Ruth, Pertwee, Roger G, Henstridge, Christopher M, Irving, Andrew J, Schulman, Jesse, Powell, Keith, Baker, Mark D, Giovannoni, Gavin, Selwood, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522996/
https://www.ncbi.nlm.nih.gov/pubmed/28677901
http://dx.doi.org/10.1111/bph.13889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522996/
https://www.ncbi.nlm.nih.gov/pubmed/28677901
http://dx.doi.org/10.1111/bph.13889

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