Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions

Malic enzyme 1 (ME1) regulates one of the main pathways that provide nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for cancer cell growth through maintenance of redox balance and biosynthesis processes in the cytoplasm. In this study, we found that ME1 inhibition disrupted...

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Detalles Bibliográficos
Autores principales: Murai, S, Ando, A, Ebara, S, Hirayama, M, Satomi, Y, Hara, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523067/
https://www.ncbi.nlm.nih.gov/pubmed/28481367
http://dx.doi.org/10.1038/oncsis.2017.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523067/
https://www.ncbi.nlm.nih.gov/pubmed/28481367
http://dx.doi.org/10.1038/oncsis.2017.34

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