Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity

Although strategies that block FOXP3-dependent regulatory T cell function (CTLA4 blockade) and the inhibitory receptor PD1 have shown great promise in promoting antitumor immune responses in humans, their widespread implementation for cancer immunotherapy has been hampered by significant off-target...

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Detalles Bibliográficos
Autores principales: Nawaf, Maher G., Ulvmar, Maria H., Withers, David R., McConnell, Fiona M., Gaspal, Fabrina M., Webb, Gwilym J., Jones, Nick D., Yagita, Hideo, Allison, James P., Lane, Peter J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2017
Materias:
Immunotherapy and Vaccines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523579/
https://www.ncbi.nlm.nih.gov/pubmed/28646041
http://dx.doi.org/10.4049/jimmunol.1700088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523579/
https://www.ncbi.nlm.nih.gov/pubmed/28646041
http://dx.doi.org/10.4049/jimmunol.1700088

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