Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection

In tuberculosis (TB), the innate inflammatory immune response drives tissue destruction, morbidity, and mortality. Monocytes secrete matrix metalloproteinases (MMPs), which have key roles in local tissue destruction and cavitation. We hypothesized that integrin signaling might regulate monocyte MMP...

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Detalles Bibliográficos
Autores principales: Brilha, Sara, Wysoczanski, Riccardo, Whittington, Ashley M., Friedland, Jon S., Porter, Joanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2017
Materias:
Infectious Disease and Host Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523580/
https://www.ncbi.nlm.nih.gov/pubmed/28646039
http://dx.doi.org/10.4049/jimmunol.1700128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523580/
https://www.ncbi.nlm.nih.gov/pubmed/28646039
http://dx.doi.org/10.4049/jimmunol.1700128

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