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Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990–2011
BACKGROUND: Surrogate endpoint trials test strategies more efficiently but are accompanied by uncertainty about the relationship between changes in surrogate markers and clinical outcomes. METHODS AND RESULTS: We identified cardiovascular trials with primary surrogate endpoints published in the New...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524035/ https://www.ncbi.nlm.nih.gov/pubmed/28325713 http://dx.doi.org/10.1161/JAHA.116.005285 |