Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRAS(G12D)-driven Pancreatic Tumorigenesis

BACKGROUND & AIMS: Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ activates the canonical SMAD pathway through its interaction with the serine/threonine kinase type I and II heterotetramer...

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Detalles Bibliográficos
Autores principales: Chuvin, Nicolas, Vincent, David F., Pommier, Roxane M., Alcaraz, Lindsay B., Gout, Johann, Caligaris, Cassandre, Yacoub, Karam, Cardot, Victoire, Roger, Elodie, Kaniewski, Bastien, Martel, Sylvie, Cintas, Celia, Goddard-Léon, Sophie, Colombe, Amélie, Valantin, Julie, Gadot, Nicolas, Servoz, Emilie, Morton, Jennifer, Goddard, Isabelle, Couvelard, Anne, Rebours, Vinciane, Guillermet, Julie, Sansom, Owen J., Treilleux, Isabelle, Valcourt, Ulrich, Sentis, Stéphanie, Dubus, Pierre, Bartholin, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524227/
https://www.ncbi.nlm.nih.gov/pubmed/28752115
http://dx.doi.org/10.1016/j.jcmgh.2017.05.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524227/
https://www.ncbi.nlm.nih.gov/pubmed/28752115
http://dx.doi.org/10.1016/j.jcmgh.2017.05.005

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