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Human Tamm-Horsfall protein, a renal specific protein, serves as a cofactor in complement 3b degradation

Tamm-Horsfall protein (THP) is an abundant urinary protein of renal origin. We hypothesize that THP can act as an inhibitor of complement since THP binds complement 1q (C1q) of the classical complement pathway, inhibits activation of this pathway, and is important in decreasing renal ischemia-reperf...

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Detalles Bibliográficos
Autor principal: Rhodes, Diana C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524369/
https://www.ncbi.nlm.nih.gov/pubmed/28742158
http://dx.doi.org/10.1371/journal.pone.0181857