Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation during the development of colitis by modulating auto...

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Detalles Bibliográficos
Autores principales: Cosin-Roger, Jesus, Simmen, Simona, Melhem, Hassan, Atrott, Kirstin, Frey-Wagner, Isabelle, Hausmann, Martin, de Vallière, Cheryl, Spalinger, Marianne R., Spielmann, Patrick, Wenger, Roland H., Zeitz, Jonas, Vavricka, Stephan R., Rogler, Gerhard, Ruiz, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/
https://www.ncbi.nlm.nih.gov/pubmed/28740109
http://dx.doi.org/10.1038/s41467-017-00213-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/
https://www.ncbi.nlm.nih.gov/pubmed/28740109
http://dx.doi.org/10.1038/s41467-017-00213-3

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