Cargando…

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates inflammation during the development of colitis by modulating auto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cosin-Roger, Jesus, Simmen, Simona, Melhem, Hassan, Atrott, Kirstin, Frey-Wagner, Isabelle, Hausmann, Martin, de Vallière, Cheryl, Spalinger, Marianne R., Spielmann, Patrick, Wenger, Roland H., Zeitz, Jonas, Vavricka, Stephan R., Rogler, Gerhard, Ruiz, Pedro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/ https://www.ncbi.nlm.nih.gov/pubmed/28740109 http://dx.doi.org/10.1038/s41467-017-00213-3

Ejemplares similares

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
por: de Vallière, Cheryl, et al.
Publicado: (2016)

Mutant HRAS as novel target for MEK and mTOR inhibitors
por: Kiessling, Michael K., et al.
Publicado: (2015)

Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium
por: Simmen, Simona, et al.
Publicado: (2018)

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
por: Cosin-Roger, Jesus, et al.
Publicado: (2018)

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome
por: Ruiz, Pedro A, et al.
Publicado: (2017)

Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis
por: Morón, Belén, et al.
Publicado: (2013)

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
por: Spalinger, Marianne R., et al.
Publicado: (2023)

Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model
por: Maeyashiki, Chiaki, et al.
Publicado: (2020)

Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy
por: Spalinger, Marianne R., et al.
Publicado: (2013)

Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity
por: Häfliger, Janine, et al.
Publicado: (2022)

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort
por: Spalinger, Marianne R., et al.
Publicado: (2016)

Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases
por: Fagagnini, Stefania, et al.
Publicado: (2017)

Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: the Altitude IBD Study
por: Vavricka, Stephan, et al.
Publicado: (2017)

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance
por: Hering, Larissa, et al.
Publicado: (2020)

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N(2) in Dendritic Cells to Protect from Elevated Colitis
por: Hering, Larissa, et al.
Publicado: (2021)

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner
por: Spalinger, Marianne R., et al.
Publicado: (2017)

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
por: Tcymbarevich, Irina V., et al.
Publicado: (2019)

pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis
por: de Vallière, Cheryl, et al.
Publicado: (2022)

Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis
por: Roth, Sofia, et al.
Publicado: (2016)

mTOR and Tumor Cachexia
por: Duval, Adrian P., et al.
Publicado: (2018)

Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis
por: Farhan, Maikel A., et al.
Publicado: (2015)

Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?
por: Becker, Eugenia, et al.
Publicado: (2016)

Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer
por: Busenhart, Philipp, et al.
Publicado: (2022)

Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma
por: Kiessling, Michael K., et al.
Publicado: (2016)

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis
por: Raselli, Tina, et al.
Publicado: (2019)

Correction: Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma
por: Kiessling, Michael K., et al.
Publicado: (2017)

Regulation of the Expression of Chaperone gp96 in Macrophages and Dendritic Cells
por: Wolfram, Lutz, et al.
Publicado: (2013)

Mechanical Stimulation Induces mTOR Signaling via an ERK-Independent Mechanism: Implications for a Direct Activation of mTOR by Phosphatidic Acid
por: You, Jae Sung, et al.
Publicado: (2012)

Anemia in Inflammatory Bowel Disease: An Under-Estimated Problem?
por: Rogler, Gerhard, et al.
Publicado: (2015)

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation
por: de Vallière, Cheryl, et al.
Publicado: (2015)

Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
por: Yang, Fan, et al.
Publicado: (2019)

Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis
por: Niechcial, Anna, et al.
Publicado: (2023)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation
por: Perren, Leonie, et al.
Publicado: (2023)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling
por: Okoye, Isobel, et al.
Publicado: (2017)

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling
por: Mei, Yu, et al.
Publicado: (2017)

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
por: Zhong, Chen, et al.
Publicado: (2019)

Hedyotis diffusa Willd. Suppresses Hepatocellular Carcinoma via Downregulating AKT/mTOR Pathways
por: Huang, Lingli, et al.
Publicado: (2021)

Downregulation of PI3K/AKT/mTOR Pathway in Juglone-Treated Bovine Oocytes
por: El-Sheikh, Marwa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rdk9s2u0jb58rr01k6gv5v8n6t