Establishing a yeast-based screening system for discovery of human GLUT5 inhibitors and activators

Human GLUT5 is a fructose-specific transporter in the glucose transporter family (GLUT, SLC2 gene family). Its substrate-specificity and tissue-specific expression make it a promising target for treatment of diabetes, metabolic syndrome and cancer, but few GLUT5 inhibitors are known. To identify and...

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Detalles Bibliográficos
Autores principales: Tripp, Joanna, Essl, Christine, Iancu, Cristina V., Boles, Eckhard, Choe, Jun-yong, Oreb, Mislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524692/
https://www.ncbi.nlm.nih.gov/pubmed/28740135
http://dx.doi.org/10.1038/s41598-017-06262-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524692/
https://www.ncbi.nlm.nih.gov/pubmed/28740135
http://dx.doi.org/10.1038/s41598-017-06262-4

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