TGF-β1 Downregulates the Expression of CX(3)CR1 by Inducing miR-27a-5p in Primary Human NK Cells

Activity of human natural killer (NK) cells against cancer cells is deeply suppressed by TGF-β1, an immunomodulatory cytokine that is released and activated in the tumor microenvironment. Moreover, our previous data showed that TGF-β1 modifies the chemokine receptor repertoire of NK cells. In partic...

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Detalles Bibliográficos
Autores principales: Regis, Stefano, Caliendo, Fabio, Dondero, Alessandra, Casu, Beatrice, Romano, Filomena, Loiacono, Fabrizio, Moretta, Alessandro, Bottino, Cristina, Castriconi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524732/
https://www.ncbi.nlm.nih.gov/pubmed/28791023
http://dx.doi.org/10.3389/fimmu.2017.00868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524732/
https://www.ncbi.nlm.nih.gov/pubmed/28791023
http://dx.doi.org/10.3389/fimmu.2017.00868

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