Stabilization of Glucocerebrosidase by Active Site Occupancy

[Image: see text] Glucocerebrosidase (GBA) is a lysosomal β-glucosidase that degrades glucosylceramide. Its deficiency results in Gaucher disease (GD). We examined the effects of active site occupancy of GBA on its structural stability. For this, we made use of cyclophellitol-derived activity-based...

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Detalles Bibliográficos
Autores principales: Ben Bdira, Fredj, Kallemeijn, Wouter W., Oussoren, Saskia V., Scheij, Saskia, Bleijlevens, Boris, Florea, Bogdan I., van Roomen, Cindy P. A. A., Ottenhoff, Roelof, van Kooten, Marielle J. F. M., Walvoort, Marthe T. C., Witte, Martin D., Boot, Rolf G., Ubbink, Marcellus, Overkleeft, Herman S., Aerts, Johannes M. F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525105/
https://www.ncbi.nlm.nih.gov/pubmed/28485919
http://dx.doi.org/10.1021/acschembio.7b00276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525105/
https://www.ncbi.nlm.nih.gov/pubmed/28485919
http://dx.doi.org/10.1021/acschembio.7b00276

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