Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

BACKGROUND: Transmembrane helices (TMHs) frequently occur amongst protein architectures as means for proteins to attach to or embed into biological membranes. Physical constraints such as the membrane’s hydrophobicity and electrostatic potential apply uniform requirements to TMHs and their flanking...

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Detalles Bibliográficos
Autores principales: Baker, James Alexander, Wong, Wing-Cheong, Eisenhaber, Birgit, Warwicker, Jim, Eisenhaber, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525207/
https://www.ncbi.nlm.nih.gov/pubmed/28738801
http://dx.doi.org/10.1186/s12915-017-0404-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525207/
https://www.ncbi.nlm.nih.gov/pubmed/28738801
http://dx.doi.org/10.1186/s12915-017-0404-4

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