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Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA

BACKGROUND: Defective interfering (DI) viruses are natural antivirals made by nearly all viruses. They have a highly deleted genome (thus being non-infectious) and interfere with the replication of genetically related infectious viruses. We have produced the first potential therapeutic DI virus for...

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Detalles Bibliográficos
Autores principales: Meng, Bo, Bentley, Kirsten, Marriott, Anthony C., Scott, Paul D., Dimmock, Nigel J., Easton, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525295/
https://www.ncbi.nlm.nih.gov/pubmed/28738877
http://dx.doi.org/10.1186/s12985-017-0805-6